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IOB |
宋麗英 助理教授 Sung, Li-Ying (Assistant Professor) Email: liyingsung@ntu.edu.tw 專長︰動物複製學 / 細胞核基因再程序化 / 牛胚體外生產 / 卵及胚冷凍技術 Expertise: Animal Cloning, Reprogramming, IVP of Bovine Embryos, Cryopreservation of Oocytes and Embryos. 連絡：生物科技所 413; Tel: 02-3366-6015~16 Contact: Room 413, 4F, No. 81, Chang-Xing St., Taipei, 106, Taiwan Tel: 886-2-33666015~16 Fax: 886-2-33666001 |
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學歷 |
2006 博士 美國康乃狄克州立大學動物科學研究所 1999 碩士 國立台灣大學動物科學與技術研究所 1996 學士 國立屏東科技大學畜產學系 |
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Education |
2006 Ph.D. Department of Animal Science, University of Connecticut, Storrs, USA 1999 M.S. Department of Animal Science, National Taiwan University, Taipei, Taiwan, ROC 1996 B.S. Department of Animal Science, National PingTung Polytechnic Institute PingTung, Taiwan, ROC |
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相關經歷 |
2006-2007 博士後研究 美國康乃狄克大學再生生物學研究中心及動物科學研究所 2001-2003 胚胎學研究員 美國康乃狄克州 Evergen Biotechnologies 公司 2000-2003 研究助理 美國康乃狄克大學再生生物學研究中心及動物科學研究所 1999-2000 研究助理 國立台灣大學動物科學與技術研究所 1996-1997 酪農輔導專員 台灣光全股份有限公司 1993-1994 研究助理 國立屏東科技大學畜產學系 |
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Experience |
2006-2007 Post-doctoral fellow, Center for Regenerative Biology and Departments of Animal Science, University of Connecticut, USA 2001-2003 Embryologist, Evergen Biotechnologies, Inc. Storrs, Connecticut, USA 2000-2003 Research Assistant, Dept. of Animal Science, University of Connecticut, USA 1999-2000 Research Assistant, Dept. of Animal Science, National Taiwan University, Taipei, Taiwan, ROC 1996-1997 Cooperative Extension Officer, Kung Chuan Dairy Co., Ltd., Taoyuan, Taiwan, ROC 1993-1994 Research Assistant, Dept. of Animal Husbandry, National Chia-Yi Institute of Agriculture, Chia-Yi, Taiwan, ROC |
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得獎記錄 Awards |
2006 美國康乃狄克州立大學農學院研究生論壇海報發表首獎 1998 中華民國畜牧學會青年科學家論文發表新人獎 1996 戈福江教授紀念獎學金
2006 First Place Poster Presentation - CANR Graduate Student Research Forum, University of Connecticut, Storrs, USA 1998 Young Scientist Paper Presentation Contest Award, the Chinese Society of Animal Science. Taiwan, ROC 1996 Winner of the Prof. F. K. Koh´s Memorial Foundation Scholarship, Prof. F. K. Koh Memorial Foundation. Taiwan, ROC |
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Courses |
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研究成果目錄 Publications |
期刊論文 Referred paper 1. Sung, L-Y., Shen, P-C., Jeong, BS., Xu, J., Chang, C-C., Cheng, WTK., Wu, J-S., Lee, S-N., Broek, D., Faber, D., Tian, XC., Yang, X., Du, F. Premature Chromosome Condensation Is Not Essential for Nuclear Reprogramming in Bovine Somatic Cell Nuclear Transfer. Biol Reprod., 2007 Feb; 76(2):232-40. 2. Sung, L-Y. Gao, S., Shen, H., Yu, H., Song, Y., Smith, S.L., Chang, C-C., Inoue, K., Kuo, K., Lian, J., Li, A., Tian, X.C., Tuck, D.P., Weissman, S.M., Cheng, T., Yang, X. Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer. Nature Genetics, 2006 Nov; 38(11): 1323-8. Epub 2006 Oct 1. 3. Yang, X., Cheng, T., Sung, L-Y,. Gao, S., Shen, H., Yu, H., Song, Y., Smith, S.L., Tuck, D.P., Inoue, K., Weissman, S.M. Reply to "On the cloning of animals from terminally differentiated cells". Nature Genetics, 2007 Feb; 39(2):137-8. 4. Yang, X., Gao, S.R., Du, F., Xu, J., and Sung, L.Y. Nuclear Transfer Cloning. Encyclopedia of Biotechnology in Agriculture and Food (EBAF), accepted review), 2007. 5. Chang, C-C., Nagy, Z. P ., Gao, S., Sung, L-Y., Enrigh, P. B., Rasmussen, T. P., Yang, X., Tian, X. C. The Genome –Wide Epigenetic Modifications during Mouse Oocyte Growth. J Biol. Chem., (in reviewing). 2007. 6. Tian, X.C., Smith, S.L., Zhang, S.Q., Kubota, C., Curchoe, C., Xue, F., Yang, L., Du, F., Sung, L-Y., Yang, X. Nuclear reprogramming by somatic cell nuclear transfer – the cattle story. Reproduction (accepted review), 2007. 7. Du, F., Shen, P.C., Xu, J., Sung, L-Y., Jeong, BS., Nedambale, L.T., Riesen, J., Tian, C.X., Cheng, W.T.K., Lee, S.N., Yang, X. The cell agglutination agent, phytohemagglutinin-L, improves the efficiency of somatic nuclear transfer cloning in cattle (Bos taurus). Theriogenology, 2006, 65(3): 642-57. 8. Smith, S.L., Everts, R.E., Tian, X.C., Du, F., Sung, L-Y., Rodriguez-Zas, S.L., Jeong, B.S., Renard, J.P., Lewin, H.A., Yang, X. Global gene expression profiles reveal significant nuclear reprogramming by the blastocyst stage after cloning. Proc Natl Acad Sci U S A. 2005, 102(49): 17582-7. 9. Enright, B.P., Sung, L-Y., Chang, C.C., Yang, X., Tian, X.C. Methylation and Acetylation Characteristics of Cloned Bovine Embryos from Donor Cells Treated with 5-aza-2'-deoxycytidine. Biol Reprod., 2005, 72: 944-948. 10. Wang, L., Duan, E., Sung, L-Y., Jeong, B-S., Yang, X., and Tian, CT. Generation and Characterization of Pluripotent Stem Cells from Cloned Bovine Embryos. Biol Reprod., 2005, 73: 149 – 155. 11. Sung, L-Y., Du, F., Xu, J., Chang, W., Jiang, S., Tian, X.C. and Yang, X. The effect of albumin and sodium citrate on the development of in vitro produced bovine embryos under different oxygen tension. Reprod Nutri Dev., 2004, 44:551-564. 12. Liu, J-L., Sung, L-Y., Du, F., Julian, M., Jiang, S., Barber, M., Xu, J., Tian, X. C. and Yang, X. Differential development of rabbit embryos derived from parthenogenesis and nuclear transfer. Mol. Reprod. Dev., 2004, 68:58-64. 13. Liu, J-L., Sung, L-Y., Barber, M., and Yang, X. Hypertonic Medium Treatment for Localization of Nuclear Material in Bovine Metaphase II Oocytes. Biol Reprod., 2002, 66: 1342 - 1349. 14. Liu, J-L., Sung, L-Y., Tian, X. C. and Yang, X. Hypertonicity-Induced Projections Reflect Cell Polarity in Mouse Metaphase II Oocytes: Involvement of Microtubules, Microfilaments, and Chromosomes. Biol Reprod., 2002, 67: 1853 - 1863. 15. Du, F., Sung, L-Y., Tian, X. C. and Yang, X. Differential cytoplast requirement for embryonic and somatic cell nuclear transfer in cattle. Mol. Reprod. Dev., 2002, 63:183-191.
ABSTRACTS 1. Sung, L-Y., Gao, S., Shen, H., Yu, H., Song, Y., Smith, S.L., Inoue, K., Tuck, D.P., Weissman, S.M., Tian, X., Cheng, T., and Yang, X. Are differentiated cells more efficient than adult stem cells for somatic cell cloning? (Connecticut ‘s Stem Cell Research International Symposium, March 27-28, 2007, Hartford, Connecticut) 2. Evert, R.E., Sommers, A., Green, C.A., Oliveira, R., Rodriguez-Zas, S., Sung L-Y., Du, F., Evans, A.C.O., Boland, M., Fair, T., Lonergan, P., Renard, J-D., Yang, X., Tian, X., Lewin, H.A. Major differences in gene experession profiles revealed in Day-25 placetal tissues collected from cows carrying cloned fetuses. (Plant and Animal Genomes XV Conference, San Diego, CA, January 13-17, 2007) 3. Du, F., Xu, J., Gao, S., Sung L-Y., Stone, D., Joyner, M., Zhang, J., Chaubal, S., Tian, X. C., Chen, Y. E., and Yang, X. Full-term and live rabbit clones produced by somatic cell nuclear transfer. (2006 IETS meeting, Orlando, Florida) 4. Smith, S. L., Sung, L-Y., Page, R., Henderson, B., Du, F., Everts, R. E., Nedambale, T., Rodriguez-Zas, S., Renard, J.-P., Lewin, H. A., Yang, X., and Tian, X. C. Expression profiling of single bovine embryos reveals significant effects of in vitro maturation, fertilization and culture. (2006 IETS meeting, Orlando, Florida) 5. Sung, L-Y., Du, F., Jeong, B.S., Chang, C.C., Xu, J., Tian, X.C., Yang, X. Premature chromosome condensation is not essential for bovine somatic nuclear reprogramming. (2005 IETS meeting, Copenhagen, Denmark) 6. Lonergan, P., Evans, A.C.O., Boland, E., Rizos, D., Sung, L-Y., Du, F., Chaubal, S., Fair, S., Scraggs, E., Duffy, P., Yang, X., Tian, X.C. Pregnancy and fetal characteristics after transfer of vitrified in vivo and cloned bovine embryos. (2005 IETS meeting, Copenhagen, Denmark) 7. Su, L., Du, F., Sung, L-Y., Yang, S., Jeong, B.S., Casinghino, S., Nedambale, T.L., Xu, J., Tian, C.X., Yang, X and Ji, W. In vitro development of Yak (Poephagus Mutus) cloned embryos by interspecies somatic nuclear transfer. Reproduction, Fertility and Development 2005; 17:183. 8. Shen, P,C., Huang, J.C., Wang, C.H., Wu, J.S., Cheng, W.T.K., Sung, L-Y., Xu, J., Tian, C.X., Yang, X., Du, F. and Lee, S.N. Pregnancy establishment of nuclear transferred embryos after vitrification and embryo transfer in cattle. Reproduction, Fertility and Development 2004; 16:209. 9. Sung, L-Y., Du, F., Xu, J., Chang, W., Jiang, S., Tian, X.C. and Yang, X. 2003. The effect of albumin and sodium citrate on the development of in vitro produced bovine embryos under different oxygen tension. (2003 IETS meeting, Auckland, New Zealand) 10. Du, F., Sung, L-Y., Jeong, B.S., Xu, J., and Riesen, J. Lectin-cell agglutination agent improves the efficiency of bovine somatic cloning. Theriogenology 2003; 59:247. 11. Liu, J-L., Sung, L-Y., Du, F., Julian, M., Jiang, S., Barber, M., Xu, J., Tian, X.C., Yang, X. Differential development of rabbit embryos derived from parthenogenesis and nuclear transfer. Theriogenology 2003; 58:271.
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