Institute of Biotechnology, College of Bio-Resources and Agriculture, National Taiwan University



李宣書 副教授 

Lee, Hsuan-Shu (Associate Professor)


專長︰ 臨床醫學 / 肝臟學 / 幹細胞學 / 再生醫學

連絡: 生物科技所 404; Tel: 3366-6007~8









中央研究院醫師研究進修獎助 (1991~1993)

公務員服務獎章 (2000)

財團法人跨世紀醫療促進基金會醫學研究獎 (2002)

臺大醫院教學優異獎 (2003)

杜聰明博士獎學基金會優秀論文獎 (2003)




  1. Chen CH, Chen GJ, Lee HS, Huang GT, Yang PM, Tsai LJ, Chen DS, Sheu JC. Expression of cancer-testis antigens in human hepatocellular carcinoma. Cancer Lett 2001; 164: 189-195.

  2. Lee HS, Huang GT, Miau LH, Chiou LL, Chen CH, Sheu JC. Expression of matrix metalloproteinases in spontaneous regression of liver fibrosis. Hepatogastroenterology 2001; 48: 1114-1117.

  3. Lee HS, Huang GT, Chen CH, Chiou LL, Lee CC, Yang PM, Chen DS, Sheu JC. Less reversal of liver fibrosis after prolonged carbon tetrachloride injection. Hepatogastroenterology 2001; 48: 1312-1315.

  4. Lee HS, Huang GT. Mesenchymal stem cells: building a new medicine in the 21st century. Formosan J Med 2001; 5: 654-657.

  5. Lee HS, Tang JL, Chiou LL, Tsai KS, Jiang CC, Yang PM, Yang PC, Huamg GT. Osteogenic differentiation of mesenchymal stem cells derived from bone marrow of patients with myeloproliferative disorders. J Formos Med Assoc 2002; 101: 124-128.

  6. Tsou PL, Lee HS, Jeng YM, Huang TS. Submassive liver necrosis in a hepatitis B carrier with Cushing’s syndrome. J Formos Med Assoc 2002; 101: 156-158.

  7. Chen TH, Chen CJ, Yen MF, Lu SN, Sun CA, Huang GT, Yang PM, Lee HS, Duffy SW. Ultrasound screening and risk factors for death from hepatocellular carcinoma in a high risk group in Taiwan. Int J Cancer 2002; 98: 257-261.

  8. Lee HS, Huang GT, Chiang H, Chiou LL, Jiang CC. Multipotential mesenchymal stem cells from femoral bone marrow near the site of osteonecrosis. Stem Cells 2003; 21: 190-199.

  9. Lee HS, Crane GG, Merok JR, Tunstead JR, Hatch NL, Panchalingam K, Powers MJ, Griffith LG, Sherley JL. Clonal expansion of adult rat hepatic stem cell lines by suppression of asymmetric cell kinetics (SACK). Biotechnol Bioeng 2003; 83: 760-771. (Selected by ISSCR as one of Stem Cell Science Literature in

 10. Lee HS, Miau LH, Chien CH, Chiou LL, Huang GT, Yang PM, Sheu JC. Differential role of p38 in IL-1a-induction of MMP-9 and MMP-13 in an established liver myofibroblast cell line. J Biomed Sci 2003; 10: 757-765.

 11. Tai TY, Lu JY, Chen CL, Lai MY, Chen PJ, Kao JH, Lee CZ, Lee HS, Chuang LM, Jeng YM. Interferon-alpha reduces insulin resistance and beta-cell secretion in responders among patients with chronic hepatitis B and C. J Endocrinol 2003; 178: 457-465.

 12. Chen MH, Lin S, Hsieh CH, Lee HS, Chiang H, Jiang CC. Identification and initial characterization of small cells in adult cartilage and bone marrow. J Formos Med Assoc 2004 ; 103: 264-273.

 13. Huang YH, Chen CH, Chang TT, Chen SC, Wang SY, Lee PC, Lee HS, Lin PW, Huang GT, Sheu JC, Tsai HM, Chau GY, Chiang JH, Lui WY, Lee SD, Wu JC. The role of transcatheter arterial embolization in patients with resectable hepatocellular carcinoma: a nation-wide, multicenter study. Liver Int 2004; 24: 419-424.

 14. Lee HS, Liu Y, Chen HC, Chiou LL, Huang GT, Lo W, Dong CY. Optical biopsy of liver fibrosis by use of multiphoton microscopy. Opt Lett 2004; 29: 2614-2616.

 15. Liang JD, Yang PM, Huang GT, Lee HS, Chen CH, Liang PC, Sheu JC, Chen DS. Percutaneous microwave coagulation therapy under ultrasound guidance for small hepatocellular carcinoma. J Formos Med Assoc 2004; 103: 908-913.

 16. Lee HS, Shun CT, Chiou LL, Chen CH, Huang GT, Sheu JC. Hydroxyproline content of needle biopsies as an objective measure of liver fibrosis: Emphasis on sampling variability. J Gastroenterol Hepatol 2005; 20: 1109-1114.

 17. Yu HJ, Lin BR, Lee HS, Shun CT, Yang CC, Lai TY, Chien CT, Hsu SM. Sympathetic vesicovascular reflex induced by acute urinary retention evokes proinflammatory and proapoptotic injury in rat livers. Am J Physiol 2005; 288: F1005-1014.

 18. Chiang H, Kuo TF, Tsai CC, She BR, Huang YY, Lee HS, Shieh CS, Chen MH, Ramshaw J, Werkmeister J, Tuan RS, Jiang CC. Repair of porcine articular cartilage defect with autologous chondrocyte transplantation. J Orthop Res 2005; 23: 584-593.

 19. Huang YH, Chen CH, Chang TT, Chen SC, Chiang JH, Lee HS, Lin PW, Huang GT, Sheu JC, Tsai HM, Lee PC, Huo TI, Lee SD, Wu JC. The role of transcatheter arterial embolization for patients with unresectable hepatocellular carcinoma: a nationwide, multicentre study evaluated by cancer stage. Aliment Pharmacol Ther. 2005; 21: 687-694.

 20. Lin YW, Lee HS, Chen CH, Huang GT, Lee PH, Sheu JC. Clonality analysis of multiple hepatocellular carcinomas by loss of heterozygosity pattern determined by chromosomes 16q and 13q. J Gastroenterol Hepatol 2005; 20: 536-546.

 21. Huang YH, Chen CH, Chang TT, Chen SC, Wang SY, Lee HS, Lin PW, Huang GT, Sheu JC, Tsai HM, Lee PC, Chau GY, Lui WY, Lee SD, Wu JC. Evaluation of predictive value of CLIP, Okuda, TNM and JIS staging systems for hepatocellular carcinoma patients undergoing surgery. J Gastroenterol Hepatol 2005; 20: 765-771.

 22. Lu JY, Chuang LM, Yang WS, Tai TY, Lai MY, Chen PJ, Kao JH, Lee CZ, Lee HS. Adiponectin levels among patients with chronic hepatitis B and C infections and in response to IFN-a therapy. Liver Int 2005; 25: 752-759.

 23. Lee HS, Sherley JL, Chen JJW, Chiu CC, Chiou LL, Liang JD, Yang PC, Huang GT, Sheu JC. EMP-1 is a junctional protein in a liver stem cell line and in the liver. Biochem Biophys Res Commun 2005; 334: 996-1003.

 24. Lee IN, Chen CH, Sheu JC, Lee HS, Huang GT, Yu CY, Lu FJ, Chow LP. Identification of Human Hepatocellular Carcinoma-Related Biomarkers by Two-Dimensional Difference Gel Electrophoresis and Mass Spectrometry. J Proteome Res 2005; 4: 2062-2069.

 25. Lee IN, Chen CH, Sheu JC, Lee HS, Huang GT, Chen DS, Yu CY, Wen CL, Lu FJ, Chow LP. Identification of complement C3a as a candidate biomarker in human chronic hepatitis C and HCV-related hepatocellular carcinoma using a proteomics approach. Proteomics (in press)

 26. Lee HS, Teng SW, Chen HC, Lo W, Lin TY, Chiou LL, Jiang CC, Dong CY. Imaging human bone marrow stem cell morphogenesis in PGA scaffold by multiphoton microscopy. Tissue Eng (in press)

 27. Liu Y, Chen HC, Yang SM, Sun JL, Lo W, Chiou LL, Huang GT, Dong CY, Lee HS (Correspondent). Visualization of hepatobiliary excretory function by intravital multiphoton microscopy. J Biomed Opt (in press)


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