生命科學院 生化科技系  >  必修課程領域必修選修課程

College of Life ScienceBST > Curriculum: CompulsoryDomainsElectives

   

BST Course Outline

列出部份課程大綱,正在收集擴大中。 Part of the course outlines in BST, the list is expanding.

Course ID

Course title

 

Status

B02 20101

生物化學 上下

Biochemistry (1) (2)  

 

B02 20301

微生物學 上

Microbiology (I)

 

B02 20302

微生物學 下

Microbiology (II)

 

B02 20310

微生物學實驗

Microbiology lab

 

B02 30070

營養生化學

Nutrition biochemistry  

 

B02 30040

微生物代謝

Microbial metabolism

 

B02 30080

營養生化學實驗

Nutrition biochemistry lab  

 

B02 U1010

生物技術概論 一

Introduction to biotechnology (I)

 

       

B47 U0350

維生素營養學

Vitamins

 

B47 U1110

微生物生技檢驗法

Biotechnological diagnosis of microorganism

 

B47 U1130

基因改造食品

Genetically modified food

 

B47 U1140

機能性食品

Functional food

 

B47 U1170

生物製程技術

Bioprocessing technology

New 2005

B47 U1210

結構生物學概論

Introduction to structural biology

New 2005

B47 U1320

荷爾蒙與調節物質

Hormone and signaling molecules

 

B47 U1430

生物膜之基礎與應用

Fundamentals and applications of biofilms

 

 

 

 

 

P05 U2010

分子生物學

Molecular biology  (slide download)

王老師講義

 

 

 

 

 研究所課程大綱  

(To mbc course outline)

B02 20301

Microbiology (I)  微生物學 上

Instructors

Shang-Shyng Yang, Chien-Yuan Chen, Ray-Shyang Hseu, Ching-Tsan Huang

Outline

 

Introduction to Microbiology

 

SSY

Microbial Structure

Microscopy

Procaryotic Cell Structure and Function

Eukaryotic Cell Structure and Function

SSY

Microbial Nutrient, Growth and Control

 

SSY

Microbial Diversity I

The Archaea

The Algae and the Protozoa

SSY

Microbial Diversity I

Taxonomy and Phylogeny

The Bacteria

The Fungi

RSH

The Viruses

General Characteristics

RSH

     
Textbook

Microbiology, Sixth edition, Prescott, Harley and Klein (Eds.) McGraw Hill Companies, 2005

Remarks

No English lecture. However, the powerpoints are prepared in English.

B02 20302

Microbiology (II)  微生物學

Instructors

Shang-Shyng Yang, Chien-Yuan Chen, Ray-Shyang Hseu, Ching-Tsan Huang

Outline

 

Microbial Metabolism

Enzyme and regulation

Energy Release and Conversion

Energy Utilization

CTH

Metabolism Diversity

Microbial Ecology

Microorganisms in Environments

CTH

Microbial Molecular Biology

Gene Structure, Replication and Mutation

Gene Expression and Regulation

Recombinant DNA Technology

CTH

Microbial Genetics and Genomics

Microbial Recombination

Microbial Genomics

CTH

Microbial Applications

Food Microbiology

Industrial Microbiology

Advanced Biotechnology

CYC

Microbial Diseases and Defense

Human infectious diseases

Innate Resistance and Immune Response

Antimicrobial Chemotherapy

CYC

     
Textbook

Microbiology, Sixth edition, Prescott, Harley and Klein (Eds.) McGraw Hill Companies, 2005. Detail schedules and lectures (CTH) are available in http://cthuang.bst.ntu.edu.tw/

Remarks

No English lecture. However, the powerpoints are prepared in English.

B02 20310

Microbiology lab  微生物學實驗

Instructors

Ching-Tsan Huang

Outline

 

Laboratory Safety

General Rules and Regulations

Aseptic Technique

Culture Media Preparation, Aseptic Technique

Isolation of Pure Cultures

Culture Transfer Techniques, Cultural Characteristics

Maintenance of Pure Cultures

Turbidimetry Determinations

The Quantitative Determination of Viable Cells

Cultivation and Morphology of Fungi

Cultivation and Enumeration of Bacteriophages

Microscopic Techniques

The Hanging drop Slide, The Measurement of Cell Numbers

The Microscopic Measurement of Microorganisms

The Staining technique of fungi, Negative Staining

Simple and Capsular Staining

Gram Staining

Spore and Acid-Fast Staining, Fluorescence Microscopy

Characteristics of Microorganisms

Chemical Agents for the Control of Microbial Growth

Biochemical Activities of Microorganisms

Identification of Unknown Bacteria (Part I)

Identification of Unknown Bacteria (Part II)

   
Textbook

Benson, H. J.  (2002)  Microbiological Application: Laboratory Manual in General Microbiology, 8th ed. The McGraw Hill Companies, Inc., Boston, MA. Detail schedules and lectures can be found in http://cthuang.bst.ntu.edu.tw/_PRIVATE/COURSE/B0220310.htm

Remarks

No English lecture. However, the lab reports in English are acceptable. Discussion with the instructors using English is encouraged

B47 U1430

Fundamentals and applications of biofilms  生物膜之基礎與應用

Instructors

Ching-Tsan Huang

Outline

Course introduction and basic concepts of microbiology

Microbial attachment and process of biofilm formation

Biofilm culture and reactor design

The qualitative and quantitative analysis of biofilms

The structure and physiology of biofilms

The physical and chemical properties of biofilms

Molecular ecology of biofilms

Impacts of biofilm formation on industry

Biofilm control (1): general consideration

Biofilm control (2): microbiological consideration

Biofilm control (3): cell to cell communication

Biofilm control (4): photodynamic therapy

Biofilm application (1): water and wastewater treatment

Biofilm application (2): bioremediation

Biofilm application (3): solid state fermentation

Textbook

Biofilms, 1990. Characklis, W.G. & Marshall, K.C. (Eds.), John Wiley & Sons, Inc.

Biofilms II: Process analysis and applications, 2000. Bryers, J.D. (Ed.), Wiley-Liss, Inc.

Biofilms in medicine, industry and environmental biotechnology, 2003. Lens, P. et al. (Eds.) IWA Publishing.

Microbial biofilms, 2004. Ghannoum, M. & O'Toole, G.A. (Eds.), American Society for Microbiology Press.

Detail schedules and lectures can be found in http://cthuang.bst.ntu.edu.tw/_PRIVATE/COURSE/B47U1430.htm  

Remarks

English lecture is available upon request. All the lecture materials and exam are in English. Discussion with the instructors using English is encouraged.

B02 U1010

Introduction to biotechnology (I)  生物技術概論 一

Instructors

黃健雄等

Outline
Instructor Topics Content References
Tzu-Ming Pan

1 Functional food

2 Genetically modified foods

Part 1 Functional food

   (1) Definition and classification of functional foods

   (2) Regulation of functional food in Taiwan

   (3) Current status of functional foods in Taiwan 

Part 2 Genetically modified foods

   (1) The advantages of GMF

   (2) Methods of gene modification

   (3) Current status of genetically modified crops

   (4) Evaluation of GMF Regulation of GMF in Taiwan

Tzu-Ming Pan: Genetically Modified Food (Juo-Jao Book Company)

Jan-Hsiung Huang

Industrial microorganisms and production methods in industrial microorganisms

 

1. Characteristics and power of industrial microorganisms

2. Application scope of industrial microorganisms

3. Methods of obtaining industrial microorganisms and strain improvement

4. Cultivation methods and working attitude

5. General procedures for isolation of fermentation products

6. Examples

 

Chung-Ming Liou

Application and Breeding in Fungal Biotechnology

The eukaryotic microorganism fungi are different from prokaryotic microorganism bacteria in genetics, physiology and morphology. Breeding based on the genetics and biochemistry of fungi are the important technology in fungal industry and fungal research. The literature will introduce fundamental breeding technology as well as some development in fungal application and industry.

D. B. Berry ed. (1988): Physiology of industrial fungi. Blackwell Scientific Publications.

David H. Griffin (1994): Fungal physiology, 2nd. Ed.. Wiley-Liss.

Kung-Ta Lee

Plant Biotechnology

1. Plant Cell Cultures

2. Plant Cell Transformation for Recombinant Protein Production

S. Duta Gupta (2005), Plant tissue culture engineering. Springer, Berlin.

Chien-chih, Yang

Protein Engineering

This subtopic will cover the basic principles of protein engineering, including concepts of protein modeling and protein structure-function relationship. Some basic tools for bioinformatics will be introduced.

 

Rong-Huay Juang

Cell Fusion and Monoclonal Antibodies

1. Basic immunology

2. Why use monoclonal antibody?

3. Cell fusion method

http://juang.bst.ntu.edu.tw/ECX

Jen-Leih Wu

Molecular Virology

1. DNA and RNA virus replication and assembling,

2. The introduction of newly emerging virus

3. New progress in important fish virus

Basic Virology. E. K. Wagner & M. J. Hewlett, 2nd Ed. 2004. Blackwell Publishing.

 

大 綱

教師 課題 內容綱要 教科書/參考資料
潘子明

1. 機能性食品

2. 基因改造食品

1. 機能性食品

  (1) 機能性食品之定義及種類

  (2) 台灣機能性食品之管理現況

  (3) 台灣機能性食品之產銷現況

2. 基因改造食品

  (1) 基因改造食品之優點

  (2) 基因轉殖之方法

  (3) 基因轉殖作物之生產現況

  (4) 基因改造食品之安全評估

  (5) 基因改造食品之管理

基因改造食品 潘子明編著 九州圖書文物有限公司

黃健雄

工業微生物及發酵生產之方法

1. 工業微生物之特性與潛力

2. 工業微生物之可能利用範圍

3. 工業微生物之取得與改良方法

4. 培養方法與態度

5. 產物分離回收步驟

6. 實例

 

劉俊民

真菌之育種及在生物技術上之應用

真菌為真核微生物,其遺傳與生理、形態與屬原核微生物之細菌不同,真菌之育種為其物質生產、生化研究上重要之技術,本課程中介紹真菌之育種,及真菌在物質生產、生化研究等生物技術方面應用之狀況。

D. B. Berry ed. (1988): Physiology of industrial fungi. Blackwell Scientific Publications

David H. Griffin (1994): Fungal physiology, 2nd. Ed.. Wiley-Liss

李昆達

植物生物技術

1. 植物細胞培養法

2. 植物基因轉殖技術與重組蛋白之生產

S. Duta Gupta (2005), Plant tissue culture engineering. Springer, Berlin.

楊健志

蛋白質工程

1. 蛋白質工程之基本觀念

2. 蛋白質分子模型

3. 蛋白質之結構與功能

 

莊榮輝

細胞融合與單株抗體

1. 基礎免疫學

2. 為何要使用單株抗體

3. 細胞融合法

http://juang.bst.ntu.edu.tw/ECX

吳金洌

分子病毒學

1. DNARNA 病毒複製及組裝

2. 目前緊急性病毒包含人畜共通病毒介紹

3. 魚類重要性病毒目前研究之成果

Basic Virology. E. K. Wagner & M. J. Hewlett, 2nd Ed. 2004. Blackwell Publishing

Remarks

Lecture in English?  No

B02 30040

Microbial metabolism  營養生化學

Instructors

黃慶璨 (Ching-Tsan Huang)

Abstract

 

Outline

Course introduction and basic concepts of microbiology

Microbial nutrients, growth and cultivation

Biocatalysis and biodegradation databases

Anabolism

Catabolism

Production and regulation of the primary and secondary metabolites

Heterologous expression and regulation

Quorum sensing and biofilms

Extremophiles and their metabolism

Ruminant microorganisms and their metabolism

Rhizobium and their metabolism

Microbial degradation of lignicellulose wastes

Microbial degradation of xenobiotic wastes

Metabolic engineering in the post-genemics era

Textbook

Microbiology, 6th edition, 2005. Prescott, Harley and Klein (Eds) McGraw Hill Companies.

Brock biology of microorganisms, 11th ed. 2003.  Madigan, Martinko and Parker (Eds.), Prentice Hall.

Lehninger Principles of Biochemistry, 4th edition, 2005. Nelson and Cox (Eds) W. H. Freeman & Co.

Biocatalysis and biodegradation, 2001. Wackett and Hershberger (Eds), American Society for Microbiology Press.

Detail schedules and lectures can be found in http://cthuang.bst.ntu.edu.tw/_PRIVATE/COURSE/B0230040.htm 

Remarks

English lecture is available upon request. All the lecture materials and exam are in English. Discussion with the instructors using English is encouraged.

B02 30070

Nutrition biochemistry  營養生化學

Instructors

黃青真 (Ching-jang Huang)、蕭寧馨

Abstract

To present the biochemical and physical bases of the utilization of nutrients and metabolism in a human context and cover the molecular, cellular, and whole-body levels.

以生物化學和生理學為基礎,說明人體的營養作用,包括人體必需營養素之化學結構和性質,營養素之功用與作用機制,人體對各營養素之消化、吸收、組織間運送分佈、同化與異化代謝、恆定調節、儲存與排泄等分子與細胞機制,組織代謝特異性與全身組織間之整合,以及與疾病之關聯。

Outline

日期

   

 

1

2/23

2

The digestive system

蕭寧馨

2

3/2

11

Macrominerals: Ca, P, Mg,

蕭寧馨

3

3/9

11

Macrominerals: Na, K, Cl

蕭寧馨

4

3/16

12

Microminerals: Fe, Zn, Cu, Se

蕭寧馨

5

3/23

12

Microminerals: I, Cr, I, Mn, Mo

蕭寧馨

6

3/30

9

Water-soluble vitamins: C, B1, B2, niacin, pantothenic acid,

蕭寧馨

7

4/6

9

Water-soluble vitamins: biotin, folate, B12, B6

蕭寧馨

8

4/13

14

Body fluid and electrolyte balance

蕭寧馨

9

4/20

 

Mid-term exam 期中考

蕭寧馨

10

4/27

4

Carbohydrate

黃青真

11

5/4

4-5

Carbohydrate; Dietary fiber

黃青真

12

5/11

6

Lipids

黃青真

13

5/18

6

Lipids

黃青真

14

5/25

7

Proteins

黃青真

15

6/1

7

Proteins

黃青真

16

6/8

8

Integration and regulation of metabolism

黃青真

17

6/15

10

Fat-soluble vitamins: A, D, E, K

黃青真

18

6/22

 

Final exam 期末考

黃青真

Textbook

Advanced Nutrition and Human Metabolism (4ed) Groff JL & Gropper SS 2005

Remarks

Lecture in English?  No

B02 30080

Nutrition biochemistry lab  營養生化學實驗

Instructors

黃青真 (Ching-jang Huang)、蕭寧馨、林璧鳳

Outline

  1) Introductions

  2) Mineral Analysis: Spectrophotometrical Methods, Blood Analysis: Hemoglobin and Hematocrit

  3) Biochemical Status Assessment of Fe and Cu: TIBC, Serum Fe and Ceruloplasmin activity

  4) Immunological Analysis of Serum Ferritin

  5) Animal Experiment (I): Test Diet Preparation

  6) Animal Experiment (II): Animal Feeding and Daily Care

  7) Animal Experiment (III): Biopsy, Gross Observation, Blood and Tissue Sampling

  8) Animal Experiment (IV): Biochemical Analysis of Blood and Tissue Samples

  9) Folate Analysis: Sample Extraction and Preparation

10) Folate Analysis: Microbiological Assay (I)

11) Folate Analysis: Microbiological Assay (II) Nutrient Intake Assessment

Textbook  
Remarks

Lecture in English?  No

B02 20101

Biochemistry (1) (2)  生物化學 上下

Instructors

Rong-Huay Juang, Ping-Du Lee, and Chien-Chih Yang

Outline

Biochemistry is designed for students who are major in Biochemical Science and Technology and related biochemistry field. Biochemistry (1) is the part I of this course and covers most of the basic knowledge of biochemistry, including chemistry for amino acids, proteins, enzymes, nucleic acids, carbohydrates and lipids. Recent advances in membrane biology and signal transduction are discussed after the lipid section. Biochemistry (2) is taught in the second term as the part II of this course. Biochemistry (2) covers the topics of bioenergetics, metabolism pathways for carbohydrate, lipids, proteins and nucleotides. How hormones regulate and integrate metabolism will summarize the part II of biochemistry. Due the students taking this course are expected to take Molecular Biology as a compulsory course, this course will not cover the details of gene expression and regulation. It is strongly recommended that students have strong background in General Biology and General Chemistry. Organic Chemistry with at least 4 credits is required before taking Biochemistry (1) and (2).

Textbook

Detail schedules are found in http://juang.bst.ntu.edu.tw/BCbasics/index.htm  Please also check https://nol.ntu.edu.tw for other information

Remarks

The course is essentially taught by Mandarin. However, the examination/test paper in English can be arranged. Discussion with the instructors using English is encouraged.

B47 U0350

Vitamins  維生素營養學

Instructors

Ching-jang Huang  黃青真

Outline

  1) Basic concept, Definition and Introduction

  2) Historical Aspects

  3) Chemical and Physiological Aspects of Vitamins

  4) Status and Recommendation Level

  5) Vitamin A: Basic Nutritional Aspect

  6) Retinoids, Differentiation and Development

  7) RAR and RXR, lessons from Knock-out mice

  8) Vitamin D: Basic Nutritional Aspect

  9) Vitamin D Receptor

10) Vitamin E: Basic Nutritional Aspect

11) Tocopherol Binding protein; New tocopherol metabolite, CEHC

12) Vitamin K: Biochemical Function, Mechanism and Status

13) Folate, Vitamin B6, Vitamin B12: Basic Nutritional Aspect

14) Folate, Vitamin B6, Vitamin B12: Hyperhomocysteinemia, Cardiovascular Disease and Cancer

Textbook

Combs, G: The Vitamins: Fundamental Aspects in Nutrition and Health, Academic Press.

Remarks

Lecture in English?  No

B47 U1110

Biotechnological diagnosis of microorganism  微生物生技檢驗法

Instructor

潘子明 (Tzu-Ming Pan)

Outline

Part 1: Content and function of biotechnological diagnosis of microorganism

Part 2: Handing of sample of biotechnological diagnosis of microorganism

Part 3: Methods of biotechnological diagnosis of microorganism

(1) Conventional and rapid microbiological methods for identification of bacteria and fungi

(2) Methods for nontraditional identification and detection of pathogens or their products

(3) Principles of automated methods for diagnostic microbiology

(4) Diagnostic immunological principles and methods

(5) Molecular typing methods

Part 4: Examples of biotechnological diagnosis of microorganism

(1) Food-borne microorganisms

(2) Legionella pneumophila

(3) Escherichia coli O157:H7

(4) Shigella

(5) Cholera

References

  1. Centers for Disease Control and National Institutes of Health. 1988. Biosafety in Microbiological and Biomedical Laboratory, 2nd Ed. H. H. S. Publication No. (NIH) 88-8395, U. S. Department of Health and Human Services. Public Health Service, Washington D.C.

  2. August, M. J., Hindler, J. A., Huber, T. W., and Sewell, D. L. 1990. Cumitech 3A, Quality Control and Quality Assurance Practices in Clinical Microbiology, Coordinating editor, Weissfeld, A. S. American Society for Microbiology, Washing D.C.

  3. National Committee for Clinical Laboratory Standards. 1990. Performance Standards for Antimicrobial Disk Susceptibility Tests─Fourth Ed. Approved Standard. NCCLS Document M2-A4. Villanova, Penn., NCCLS.

  4. Stager, C. E. and Davis, J. R. 1992. Automated Systems for Identification of Microorganisms. Clin. Microbiolo. Rev. 5: 302.

  5. Persing, D. H., Smith, T. F., Tenover, F. C. and White, T. J., 1993. Diagnostic Molecular Microbiology: Principles and Applications. American Society for Microbiology, Washington, D.C.

  6. Persing, D. H., 1996. PCR Protocols for Emerging Infectious Disease (A Supplement to Diagnostic Molecular Microbiology: Principles and Applications). American Society for Microbiology, Washington, D.C.

  7. Limberger, R. J. Biega, R., Evancor, A. et. al. 1992. Evaluation of Culture and the Gen-Probe PAGE 2 Assay for Detection of Neisseria gonorrhoeae and Chlamydia trachomatis in Endocervical Specimens Transported to a State Health Laboratory. J. in. Microbiol. 30: 1162.

  8. Philipp, G., Murray, G. E., Willis, A. W. et. al. 1994. Methods for General and Molecular Bacteriology, American Society for Microbiology, Washington, D.C.

  9. Isenberg, H. D., 1992. Clinical Microbiology Procedures Handbook, American Society for Microbiology, Washington, D.C.

10. Isenberg, H. D., 1994. Clinical Microbiology Procedures Handbook, Supplement 1, American Society for Microbiology, Washington, D.C.

11. Murray, P. R.,1996, ASM Pocket Guide to Clinical Microbiology, American Society for Microbiology, Washington, D.C.

12. Hurst, C. J., Kundsen, G. R., McInerney M. J., Stetzenbach, L. D., Walter, M. V., 1997, Manual of Environmental Microbiology, American Society for Microbiology, Washington, D.C.

13. Rose, N. R., Macario, E. C., Folds, J. D., Lane, H. C., Nakamura, R., 1997, Manual of Clinical Laboratory Immunology, 5th Ed. American Society for Microbiology, Washington, D.C.

14. Demain, A. L., and Davies J. E., 1999, Manual of Industrial Microbiology and Biotechnology, American Society for Microbiology, Washington, D.C.

15. Doyle, M. P., Beuchat, L. R., Montville, T. J., 1997, Food Microbiology—Fundamentals and Frontiers, American Society for Microbiology, Washington, D.C.

16. Scheppler, J. A., Cassin, P. E., Gambier, R. M., 2000, Biotechnology Explorations, Applying the Fundamentals, American Society for Microbiology, Washington, D.C.

17. Fleming D. O., Hunt, D. L., 2000, Biological Safety, Principles and Practices, American Society for Microbiology, Washington, D.C.

18. Isenberg, H. D., 1998. Essential Procedures for Clinical Microbiology , American Society for Microbiology, Washington, D.C.

Remarks

Lecture in English?  No

B47 U1130

Genetically modified food  基因改造食品

Instructor

潘子明 (Tzu-Ming Pan)

Outline

1. Introduction

2. Genetically modified organism and genetically modified food

3. Theory of gene modification

4. Advantage of genetically modified food

5. Evaluation of genetically modified food

6. Genetically modified soybean

7. Genetically modified maize

8. Detection of genetically modified food

9. Labeling of genetically modified food

References

  1. 潘子明 2004 基因改造食品 九州圖書文物有限公司

  2. 潘子明,基因改造食品檢驗方法總論,基因改造食品之貿易管理、檢驗與標示研討會論文集,中華民國八十九年十一月七日 中國農業化學會 pp. 27-85.

  3. 潘子明 2001 食品生物技術 藝軒圖書出版社

  4. 蘇遠志 2000 基因食物面面觀 元氣齋出版社

  5. 殷麗君 孔瑾 李再貴 2002 轉基因食品 化學工業出版社

  6. Tzu-Ming Pan, 2002, Current status and detection of genetically modified organism, J Food Drug Analysis, 10: 229-241.

  7. Tzu-Ming Pan, 2002, Benefit and impact of genetically modified organism, Bioindustry, 13: 441-451.

  8. Tzu-Ming Pan, Tsung-Wei Shih, 2003, Detection of genetically modified soybeans in miso by the polymerase chain reaction and nested polymerase chain reaction, J Food Drug Analysis, 11: (in press).

  9. Tzu-Ming Pan, Tsung-Wei Shih, 2003, Detection of genetically modified soybeans in Chou-Tou-Fu and Tou-Fu-Ju by the polymerase chain reaction, Taiwanese J Agri Chem & Food Sci., 40: (in press).

10. Hsin-Ying Huang and Tzu-Ming Pan, 2003, Detection of genetically modified soybean in Miso (bean paste) and Chou-Tou-Fu (fetid bean curd) by real-time PCR, Food Sci Agri Chem., 4; (in press).

11. Kreuzer, Helen, Massey, Adrianne, 2001, Recombinant DNA and Biotechnology, 2nd Ed., American Society for Microbiology, Washington, D.C.

12. Persing, D. H., 1996. PCR Protocols for Emerging Infectious Disease (A Supplement to Diagnostic Molecular Microbiology: Principles and Applications). American Society for Microbiology, Washington, D.C.

13. Doyle, M. P., Beuchat, L. R., Montville, T. J., 1997, Food Microbiology—Fundamentals and Frontiers, American Society for Microbiology, Washington, D.C.

14. Reischl, U., Wittwer, C., Cockerill, F. 2002, Rapid Cycle Real-Time PCR— Methods and Application, Springer Co., New York.

Remarks

Lecture in English?  No

B47 U1140

Functional food  機能性食品

Instructors

潘子明 (Tzu-Ming Pan), 李敏雄 (Min-Hsung Lee), 賴喜美 (She-Mang Lay), 蘇南維 (Nan-Wei Su)

Outline

1.  Introduction

2.  Safety evaluation

3.  Analysis of functional composition

4.  Processing of functional food

5.  Functional dairy

6.  Peptide and protein

7.  Dietary supplement

8.  Vitamins and mineral

9.  Lipid and health

10.  Antioxidant

11.  Active ingredient of soybean

12.  Red mold rice

13.  Lactic acid bacteria 

References

  1. 潘子明 機能性醱酵製品總論 機能性醱酵製品研討會論文集 中華民國九十年九月五日 中國農業化學會pp. 1-65.

  2. 潘子明 2001 機能性醱酵製品 藝軒圖書出版社

  3. 于守洋  崔洪斌 2001 中國保健食品的進展  人民衛生出版社

  4. 何照范  張迪清 1998 保健食品化學及其檢測技術  中國輕工業出版社

  5. Schmidl, MK, Labuza, TP, 2000, Essentials of Functional Foods, An Aspen Publication, Gaithersburg, Maryland.

  6. Fuller R. and Perdigon, AG, 2000, Probiotics - Immunomodulation by the Gut Microflora and Probiotics, Kluwer Academic Publishers, Netherlands.

  7. Tzu-Ming Pan, 2002, Evaluation of healthy function of functional food, Bioindustry, 13: 464-473.

  8. Tzu-Ming Pan and Jun-Lin Lee, 2002, Functional food - Red mold rice, Bioindustry, 13: 488-494.

  9. Tzu-Ming Pan and Je-Yu Lu, 2002, Lactic acid bacteria and cholesterol, Bioindustry, 13: 485-489.

10.Yuan-Chi Su, Jyh-Jye Wang, Tzu-Tsen Lin and Tzu-Ming Pan, 2003, Study of the Production of the Secondary Metabolites γ-Aminobutyric Acid and Monacolin K by Fermentation of Monascus. J Ind Microb Biotech., 30:41-46.

11. Tzu-Ming Pan, Chiu-Hsia Chiu, and Yuan-Kuang Guu, 2002, Characterization of Lactobacillus isolates from pickled vegetables for use as dietary or pickle adjuncts, Food & Food Ingred. Japan, 206: 45-51.

12.Yi-Ting Hsieh and Tzu-Ming Pan, 2002, The analytical methods and assays for secondary metabolites of Monascus products, J Biomass Energy Soc., 21: 63-71.

13. Ai-Ling Cheng, Tzu-Ming Pan, Hui-Ping Hung and Ching-Jang Huang, 2000, Intestinal microflora is improved by the feeding of an oligosaccharide containing soft drink in rats, Nutr Sci J, 25: 233-243.

Remarks

Lecture in English?  No

B47 U1170

Bioprocessing technology  生物製程技術

Instructors

楊尚天 (Prof. Shang-Tian Yang) Ohio State University, Department of Chemical and Biomolecular Engineering

Introduction

Bioprocessing for Value-Added Products from Renewable Resources: New Technologies and Applications

      This course will provide a comprehensive review on the fundamentals in biotechnology and bioprocess engineering as well as industrial examples of new bio-based products and advancements in technology development that are important to the general field of bioprocessing for value-added products from renewable resources.  This course will first discuss modern technologies in the fields of genetic engineering and bioprocess engineering that are the cornerstones for building a new bio-based products industry.  The course will review different organisms, ranging from bacteria to algae, that are suitable for bioprocessing with respective to their unique characteristics, process requirements, products, and applications. This course also will review important pretreatment and processing technologies for economical use of renewable resources as the feedstock to produce industrial products. Finally, a variety of unconventional and novel bioprocesses currently in development also will be discussed.

Outline

Tentative Topics:

 1.  Introduction

 2.  Applications of genomics and proteomics for bioprocess development

 3.  Genetic engineering and directed evolution tools in bioproduct and process development

 4.  Metabolic engineering: successful examples and challenges

 5.  Combinatorial biocatalysis and high throughput screening

 6.  Bioreactor engineering – from laboratory research to industrial production

 7.  Bioseparations

 8.  Pretreatments and hydrolysis of liganocellulosic biomass

 9.  Bacterial and yeast cultures – process characteristics, products, and applications

10. Filamentous fungal cultures

11. Plant cell and microalgae cultures

12. Biocatalysis for chiral synthesis

13. Immobilized cell fermentation for production of chemicals and fuels

14. Solid state fermentation and its applications

References

 

Remarks

Lecture in English?  (on request)

B47 U1210

Introduction to structural biology  結構生物學概論

Instructors

楊啟伸

開課理由

Introduction

本課程之教學目標,在於使學生對現代結構生學之內容、重要性和其未來發展,有一較為全面而完整的認識。鑑於在最近的生命科學發展中,約略是以生命生理、結構生物、生命作用動態、生物資訊以及生命科技應用為五大發展方向。而就此目前之發展趨勢來說來分析,其中以結構生物和任何其它四個發展方向結合,無疑地已成為追求更深入之生命知識和科技研究的主要潮流之一。

本校目前有一類似但目標不相同的課程,是蛋白質結構與功能 (P05 U3230)。而與本課程部分內容將會和生物物理學 (B02 30100), 蛋白質體學 (P05 U9120) 以及生物資訊學 (P05 U9140)有關連。本課程在教學內容設計上,是以結構生物領域之整體觀念為主要養成目標,以理論、研究方法以及實際成功例子的三合一角度來引導學生對結構生物的全面認識。學生修畢之後,對於以上提及的四個學科之學習,將有十分正面之輔助效果。

課程目的

Goal

本課程之目的,在於藉由結合理論、研究方法 (包括重要結構生物電腦軟體之學習和使用) 和在每一個主題中的多個經典之成功案例來解釋結構生物學,使生化科技學系學生以及欲對結構生物學有興趣之他系學生,可以有系統地熟悉結構生物學之實質研究內容和方法,並對結構生物學之優點和貢獻有完整而清晰之認識。

課程設計

Course structure

本課程包括 16 個單元,課程架構概述如下:

1. 課程介紹 (單元 1)

2. 結構生物學之基本知識 (單元 2、3)

3. 蛋白各級結構和其四大主要功能 (單元 4、5)

4. 結構生物學之研究方法和工具 (單元 6、7、8)

5. 蛋白結構之形成、摺疊 (folding) 和蛋白品質之控制 (單元 9)

6. 蛋白結構預測和生物環境對蛋白功能之影響 (單元 10)

7. 以結構生物觀點看生命科學 (單元 11-15)

8. 結構生物學的未來動向和生物科技應用 (單元 16)

除教學課程外,學生將有指定之軟體使用作業,以提供實際學習應用之訓練。

Outline

單元

課程進度、內容及教學方式

1

結構生物之內容介紹︰結構生物學內容以及其在現代生命科學之功能和角色

2

結構生物學之基本知識 (一)蛋白質的最基本組合方塊—胺基酸以及有多種風貌的蛋白結構。

3

結構生物學之基本知識 (二)結構生物學之研究工具—包括解析蛋白結之方法、蛋白結構展示和分析軟體、各式的生物資訊 (bioinformatics) 分析資源

4

蛋白各級結構和其四大主要功能 (一) - 蛋白之各級結構詳論、結構功能區塊 (functional domain)、蛋白之形變 (conformational change) 結構之作用小單位 (motif) 以及結構間的作用力。

5

蛋白各級結構和其四大主要功能 (二) - 蛋白結構和以下四大主要功能之探討1. 蛋白結合 (binding), 2. 功能催化 (catalysis), 3. 結構變化樞鈕 (switching), 4. 生物組織之構成 (structural proteins)。

6

結構生物學之研究方法和工具 (一) - 結構之決定X-ray 結晶繞射法、核磁共振法 (NMR)、電子顯微鏡影像分析法 (single particle analysis) 以及其他傳統生物化學方法。

7

結構生物學之研究方法和工具 (二) - 結構之展示和分析 PDB 蛋白結構檔案格式之詳論、蛋白結構之 3D 展示、蛋白結構之資訊分析、電腦軟體之獲得和使用︰包括 DeepView, WebLab Pro, Chimera, PyMol, MolMol 2k.2 等軟體。

8

結構生物學之研究方法和工具 (三) - 蛋白順序之比對、分析和結構之預測︰Lasergene DNA Star suite , Blast 和 SMART 結構比對網站, Clustal V, W。

9

蛋白結構之形成、摺疊 (folding) 和蛋白品質之控制。

10

蛋白結構預測和生物環境對蛋白功能之影響

11

以結構生物觀點看生命科學 (一)細胞內的生理控制

12

以結構生物觀點看生命科學 (二)膜蛋白專論

13

以結構生物觀點看生命科學 (三)光感系統

14

以結構生物觀點看生命科學 (四)G-蛋白系統

15

以結構生物觀點看生命科學 (五)大腸桿菌化學感應系統 (chemotaxis two component system)

16

結構生物學的未來動向和生物科技應用

References

1. Gregory A. Petsko and Dagmar Ringe (2003) Protein Structure and Function, 4th ed., New Science Press, Waltham, MA

2. Carl-Ivar Branden and John Tooze. (1999) Introduction to Protein Structure, 2nd ed., Garland Publishing, New York

3. 教學內容也以科學期刊而隨時更新

Remarks

Lecture in English?  (on request)

B47 U1320

Hormone and signaling molecules  荷爾蒙與調節物質

Instructors

Ching-jang Huang  黃青真

Outline

荷爾蒙與調節物質乃人類與其他複雜之多細胞高等生物個體,對應環境改變時維持體內之恆定最重要的調節分子。其與正常生理及疾病關係十分密切。開授本課程係為使本系學生了解各種荷爾蒙與調節物質之生理、生化與分子作用機制,加強生化科技學系學生在生化領域的基礎,以利未來從事生化代謝、生理功能、分子生物及各種生物醫學相關領域等之研究。本課程將自生命個體整體巨觀 (生理) 之調節,至微觀之分子作用機制,介紹荷爾蒙與調節物質,使學生具有完整之概念。

Schedule

Date

Work

Lecturer

9/20

1.老師出國開會請假 (11/15 補課)

 

9/27

2. General Consideration and Overview

黃青真

10/4

3. Hypothalamic Releasing hormones and Posterior Pituitary Hormone (改成星期二 7, 8 節於原教室上課)

黃火鍊

10/11

4. Anterior Pituitary and Pineal Hormones

(改成星期二 7, 8 節於原教室上課)

黃火鍊

10/18

5. Steroid Hormones: Chemistry, Biosynthesis and Metabolism

黃青真

10/25

6. Adrenal Hormones

黃青真

11/1

7. Androgens, Estrogens and Progestins

黃青真

11/8

8. Hormones of Pregnancy and Lactation

黃青真

11/15

9. 期中考

 

11/22

10. Gastro-Intestinal Hormones

黃青真

11/29

11. Pancreatic Hormones

黃青真

12/6

12. Adipokine and Lipid Sensor Molecules

黃青真

12/13

13. Thyroid and Calcium Regulating hormones

黃青真

12/20

14. Eicosanoids

黃青真

12/27

15. Kidney and Cardiovascular System Hormone

黃青真

1/3

16. Introduction to plant hormone

楊建志

1/10

17. Cell Growth Factors

李明亭

Textbook

1. Norman, AW & Litwack, G (2000) Hormones. 2nd edition, Academic Press .

2. Bolander, FF. (2004) Molecular Endocrinology.  3rd ed. Elsevier Academic Press

3. Williams, RH. & Larsen, P. R (2003) Williams Textbook of Endocrinology. 10th ed. W.B. Saunders.

Web sites

https://ceiba.ntu.edu.tw

https://ceiba.ntu.edu.tw/941hormone

Remarks

Lecture in English?  No

 

P05 U2010

Molecular biology  分子生物學

Instructors

王愛玉等

Download

下載王老師部份的上課檔案 (檔案已經移除)

週次

日期

單元主題

7

10/31 

DNA replication (Chapters 13, 14)

7

11/03

DNA replication (Chapters 13, 14)

8

11/10

DNA replication (Chapters 13, 14)

8

11/07

DNA replication (Chapters 13, 14)

9

11/14

Recombination (Chapter 15)

9

11/17

2nd Exam

10

11/21

Recombination and DNA Repair (Chapter 15)  

10

11/24

DNA Repair (Chapter 15) Transposons (Chapter 16)  

11

11/28

Transposons (Chapter 16) Retroviruses and retrotransposons

Textbook

B. Lewin: Genes VIII (2004)

Linking

https://ceiba.ntu.edu.tw/941mb94_1/

 

B02

Title  課題

Instructors

教師姓名

Outline

1) 課程

Textbook  
Remarks

Lecture in English?  No

2006/02/26   Juang RH